Group Members

Name

E-mail

Adress

Research Interests

ABRINK, Magnus

magnus.abrink(at)slu.se

Dept of Biomedical Sciences & Veterinary Public Health, Swedish University of Agricultural Sciences, Box 588, Biomedical Center, Husargatan 3, SE-751 23 Uppsala, Sweden
Tel: +46-(0)18-471 4571

AROCK, Michel

michel.arock(at)psl.aphp.fr

LBPA CNRS UMR 8113
Ecole Normale Supérieure de Cachan, 61, Ave du Président Wilson, 94235 Cachan Cedex, France
Tel: 33 1 47407685

Pathophysiological studies of mastocytosis as well as in the classification of mast cell activation syndromes

BAMBOUSKOVA, Monika

monika.bambouskova(at)img.cas.cz

Dept of Signal Transduction, Institute of Molecular Genetics,
Academy of Sciences of the Czech Republic, Videnska 1083,
CZ-142 20 Prague 4, Czech Republic
Tel: 420-241 062 468
Fax: 420-241 062 214

BEN ZIMRA, Micha

micha.ben-zimra(at)mail.huji.ac.il

Dept. of  Pharmacology, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel
Tel: 972-2-6758746
Fax: 972-2-6758144

The inhibitory receptors on mast cells; non IgE-mediated mast cell activation
See also F Levi-Schaffer

BOTANA, Luis M

Luis.Botana(at)usc.es

Dept Farmacología
Fac Veterinaria
27002 Lugo, Spain
Tel: + 34 982 822 233
Fax: + 34 982 252 242

Mechanism of activation of human mast cells, specially PKC mediated effects, mitochondrial and cAMP effects, Aurora Kinase and role of c-Kit on kinase dependent pathways

BRIDT, Chris

chris.bridts(at)ua.ac.be

University of Antwerp, Faculty of Medicine, Immunology - Allergology - Rheumatology, Universiteitsplein 1 2610 Antwerpen Belgium
Tel. +32 3 2652594
Fax +32 3 2652655

BULFONE-PAUS, Silvia

sbulfone(at)fz-borstel.de

Dept. of Immunology and Cell Biology, Research Center Borstel,  Parkallee 2, D-23845 Borstel, Germany
Tel. +49 4537 188 200
Fax +49 4537 188 403

The group is devoted to contribute to dissecting
1. The complex network of receptor and adaptor proteins involved in IgE-mediated mast cell activation and degranulation.
2. The role of mast cells in the modulation of adaptive immunity and have previously shown that mast cells engage in direct interactions with T cells. The resulting cross-talk seems to be bi-directional as both partners influence the behavior of the other. Therefore we are interested in understanding mechanisms of mast cell-T cell interactions and resulting consequences.
3. Due to the expression of a large set of immune receptors and their ability to release a large number of pre-formed and newly synthesized mediators, MCs are known to initiate and control innate and adaptive immune responses against bacteria and parasites; however, the role of MCs during viral infections has not been characterized. Thus, we aimed to define the role of MCs on the immune response against influenza virus infection.

CHATTERJEA, Devavani

chatterjead(at)macalester.edu

213 Olin Price Hall
Macalester College
1600 Grand Ave.
St. Paul, MN 55105, USA
Phone: 651.696.6621
Fax: 651.696.6443

CHARLES, Nicolas
Young Ambassador, WG1
MC Substitute Member

nicolas.charles(at)inserm.fr

INSERM U699 16 rue Henri Huchard, Facult de Mdecine Xavier Bichat 75018 Paris France
Tel. +33157277306

DE MARCO, Ario
Pending MC Member

ario.de-marco(at)curie.fr
ario.demarco(at)ung.si

University of Nova Gorica (UNG)
Rožna Dolina (Nova Gorica)
Slovenia
Tel. 0039.3493542056

Receptor-ligand interactions: we have a specific expertise in recovering antibodies that recognize functional epitopes blocking molecular interactions. These antibodies can be either agonist or antagonist and can be combined in bispecific (multispecific) molecules that have the capacity of binding simultaneously two epitopes on the same or on different antigens. Such technology can be exploited for both studying the receptor-ligand interaction mechanisms and their effect on the cell signal cascade regulation and for designing drugs.
-- Review/Chapter: the above concept –trimmed on specific allergy issues- can be developed as a contribution to a WP1 publication

DRABER, Pavel
MC Substitute Member

paveldra(at)img.cas.cz

Institute of Molecular Genetics, Dept Biol Cytoskeleton, Videnska 1083 14220 Prague 4 Czech Republic
Tel. +420 241062632
Fax +420 241062758

Understanding of mechanisms that lead to rapid reorganization of cytoskeleton during mast cell activation. We concentrate mainly on signalling molecules affecting microtubule dynamics on plus ends of microtubules as well as on signalling molecules that interact with key components for microtubule nucleation (gamma-tubulin and gamma-complex proteins).

DRABER, Petr
Vice-Chair, WG1
MC Member

draberpe(at)img.cas.cz

Dept of Signal Transduction, Institute of Molecular Genetics,
Academy of Sciences of the Czech Republic, Videnska 1083,
CZ-142 20 Prague 4, Czech Republic
Tel: 420-241 062 468
Fax: 420-241 062 214

Detailed understanding at molecular level of the role of transmembrane adaptor proteins (e.g. NTAL, PAG, LAT) and some other signal transduction molecules (e.g. STIM1) in mast cell activation events, involving Ca2+ mobilization, degranulation, cellular spreading, migration, chemotaxis and others. Specifically we are interested in understanding the role of actin and other cytoskeletal components and their regulators in mast cell triggering. To this end, various methods are used to manipulate with protein expression (knock-out and knock-down approaches and lentiviral-mediated transduction of wild-type and mutated molecules). Topography of plasma membrane-associated molecules is analyzed by light (confocal microscopy) and electron microscopy (on isolated plasma membrane sheets). Kinetics of intermolecular interactions are studied by Fluorescence resonance energy transfer. Specifically we are interested in understanding the role of actin and other cytoskeletal components and their regulators in mast cell triggering.

DY, Michel

michel.dy(at)parisdescartes.fr
umr8147(at)udr1.cnrs.fr
(secretary)

CNRS UMR 8147, Cytokines, Hématopoïèse et Réponse Immune, Université René Descartes Paris V, Hôpital Necker, Paris, France

EBO, Didier

didier.ebo(at)ua.ac.be

Department of Immunology-Allergology-Rheumatology, Faculty of Medicine, University of Antwerp, Antwerp, Belgium

- Flow-assisted analysis of in vitro activated human basophils with a particular focus on its application in allergy. In this context we focus on allergy diagnosis & follow-up of allergen specific immunotherapy.
- Furthermore, we delivered the proof-of-concept that also intracellular signalling

ESCRIBANO, Luis
MC Member

lescribanom(at)sescam.jccm.es

Hospital Virgen del Valle, Instituto de Mastocitosis de Castilla La Mancha, Carretera de Cobisa s/n 45071 Toledo Spain
Tel: 34-925269335

FALCONE, Franco

Franco.Falcone(at)nottingham.ac.uk

The School of Pharmacy,  Division of Molecular and Cellular Science, Boots Science Building, Science Road, Nottingham NG7 2RD, UK
Tel: 44 (0)115 8466073; Fax: 44(0)115 9515102

FANG, Yu

yu.fang(at)microbio.gu.se

Department of Microbiology and Immunology, Sahlgrenska Academy, University of Gothenburg, Box 435, 40530 Gothenburg, Sweden
Tel: +46-31-7866322
Fax: +46-31-7866330

FOERSTER, Anja

anja.foerster_(at)uk-koeln.de

Dept of Dermatology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany
Phone: +49-221-478-3196
Fax: +49-221-478-6438

FOIA, Liliana

lilifoia(at)yahoo.co.ik

Dept. Biochemistry, University of Medicine and Pharmacy, Iasi, Romania RO-700115
Tel: 0040744704452

FREYSDOTTIR, Jona

jonaf(at)landspitali.is

Landspitali - The National University Hospital of Iceland, Dept. of Immunology and Centre for Rheumatology Research, Hringbraut (Bld 14 at Eiriksgata), 101 Reykjavik, Iceland
Tel: +354 543 6852 / + 354 861 2056
Fax: +354 543 4828

Inflammation and mainly how to alleviate chronic inflammation. Two major projects aim to determine the effects of omega-3 fatty acids on immune parameters in animal models of inflammation and the effects of natural compounds from Icelandic nature on the activation of human dendritic cells and their subsequent stimulation of T cells.

FRIEDMAN, Sheli

sheli0910(at)gmail.com

Dept. of  Pharmacology, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, The Hebrew Univ of Jerusalem, POB 12065, Jerusalem 91120, Israel
Tel:972-2-6758746;
Fax: 972-2-6758144

Autism and mast cells.
See also F Levi-Schaffer

FROSSI, Barbara

barbara.fross(at)uniud.it

Lab of Immunology
Department of Medical and Biological Science
University of Udine
P.le M. Kolbe, 4
33100 Udine - Italy
Ph. +39 0432 494342
FAX +39 0432 494301

Autoimmunity/Allergy, mast activation and signal transduction

FUX, Michaela
MC Member

michaela.fux(at)insel.ch

Institute of Immunology
Inselspital
Sahlihaus 1, Office 109
CH-3010 Bern
Tel: +41 31 632 0689
Fax: +41 31 381 5765

We are investigating the effects of different triggers including growth factors, cytokines and IgER-dependent and -independent stimuli on different primary immune cells involved in allergic inflammation with the main focus on human blood basophils. Our research aims to break down the effects of mediators activating and arresting human basophils into the specific signaling pathways and to indentify and characterize basophil-derived products upon such a treatment.

GIBBS, Bernhard
MC Member

B.F.Gibbs(at)kent.ac.uk

University of Kent, Medway School of Pharmacy, Central Avenue, ME4 4TB Chatham Maritime, UK
Tel: 44 (0)1634 20 2953

My group is dedicated to understanding the biological functions of human basophils and mast cells in relation to allergic inflammation. This includes discovering new agents that display anti-allergic properties in these cells and may be further developed into new therapies for allergies. Specifically, our group focuses on the following areas:
1) Elucidating FceRI-mediated signal transduction in human basophils; 2) Pharmacalogical regulation of mast cell and basophil mediator production; 3) Heterogeneity of mast cells and basophils; 4) Role of mast cells and basophils in allergic diseases and innate immunity to parasites; 5) Regulation of basophil priming by NGF

GIMINEZ-RIVERA, Andrey

Vladimir-Andrey.Gimenez-Rivera(at)charite.de

Dept of Dermatology and Allergy,  Allergie Centrum Charité/ECARF, Charité - Universitätsmedizin Berlin,
Charitéplatz 1 - 10117 Berlin, Germany

See Frank Siebenhaar for Research Interests

GONZALEZ, Nestor

ngonzalez(at)fz-borstel.de

Dept. of Immunology and Cell Biology, Research Center Borstel,  Parkallee 2, D-23845 Borstel, Germany
Tel. +49 4537 188 200
Fax +49 4537 188 403

GRI, Giorgia

giorgia.gri(at)uniud.it

Lab of Immunology
Department of Medical and Biological Science
University of Udine
P.le M. Kolbe, 4
33100 Udine – Italy
Ph. +39 0432 494342
FAX +39 0432 494301

Tumor immunology, cell- cell interaction

GROOT KORMELINK, Tom

Division of Pharmacology,
Dept of Pharmaceutical Sciences, Faculty of Science, Utrecht University, PO BOX 80082, 3508 TB Utrecht, The Netherlands

See Frank Redegeld for research interests.

GROSICKI, Marek

grosickim(at)gmail.com

Department of Technology and Biotechnology of Drugs
Collegium Medicum, Jagiellonian University
Medyczna 9 st., Pl 30-688 Krakow/Poland
tel. 48 (12) 6205580, 6205581
fax: 48 (12) 6205596

Immune actions of granulocytes especially in the field of histamine and H4R receptor interactions, an interesting target for innovative therapies
See also Katarzyna Kiec-Kononowicz for research interests.

HAJKOVA, Zuzana

hajkovaz(at)img.cas.cz

Institute of Molecular Genetics, Dept Biol Cytoskeleton, Videnska 1083 14220 Prague 4, Czech Republic
Tel. +420 241062632
Fax +420 241062758

HALLGREN, Jenny
MC Member

jenny.hallgren@imbim.uu.se

Uppsala University, Dept. Medical Biochemistry and Microbiology, Biomedical Center, Husargatan 3, A8:2 75123 Uppsala Sweden
Tel. +46 18 471 4676

Mast cell migration and trafficking pathways, preclinical mouse models (allergic asthma, viral infections)

HALOVA, Ivana

Ivana.halova(at)img.cas.cz

Dept of Signal Transduction, Institute of Molecular Genetics,
Academy of Sciences of the Czech Republic, Videnska 1083,
CZ-142 20 Prague 4, Czech Republic
Tel: 420-241 062 468; Fax: 420-241 062 214

HARTMANN, Karin

karin.hartmann(at)uni-koeln.de

Dept of Dermatology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany
Phone: +49-221-478-3196
Fax: +49-221-478-6438

Modulation of the tumor microenvironment by mast cells using novel mouse models for genetic mast cell deficiency and mast cell-specific gene inactivation

KADIYSKY, Dimitar
MC Member

dimkad(at)bas.bg

Institute of Experimental Morphology, Pathology and Antrhopology with Museum
Acad. G. Bonchev Str., Bl.25
1113 Sofia, Bulgaria
Tel. 00359(2)8720734; 00359(2)979 3738;
Fax. 00359(2)8719007

KARRA, Laila

lailak24(at)gmail.com

Dept. of  Pharmacology, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel
Tel:972-2-6758746
Fax: 972-2-6758144

Inhibitory receptors on Mast cells and eosinophils in health and in disease
-- The CD300a receptor as a key inhibitory receptor in modulation and termination of the allergic response
-- Resolution of allergic inflammation  (“resolvome”)
See also F Levi-Schaffer

KIEC-KONONOWICZ, Katarzyna

mfkonono(at)cyf-kr.edu.pl

Department of Technology and Biotechnology of Drugs
Collegium Medicum, Jagiellonian University
Medyczna 9 st., Pl 30-688 Krakow/Poland
tel. 48 (12) 6205580, 6205581
fax: 48 (12) 6205596

eosinophils and histamine receptors (at the first place H4), influence on them of known ligands and new compounds

KNOL, Edward F.

e.f.knol(at)umcutrecht.nl

University Medical Center Utrecht, Dept. Dermatology/ Allergology, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Tel: 31-88-7556267, Fax: 31-88-7555404
www.dermatologyutrecht.nl

KONSTANTINOS, Kyriakidis

kkyriak(at)med.uoa.gr

Department of Pharmacology,
Medical School University of Athens, Greece

H3R/H4R in inflammation & blood vessels

KONSTANTINOS, Papamichael

kpapamdoc(at)yahoo.gr

Department of Pharmacology,
Medical School University of Athens, Greece

histamine in inflammatory bowel disease

LEVI-SCHAFFER, Francesca
Chair, WG1, MC Member

francescal(at)ekmd.huji.ac.il

Dept. of  Pharmacology, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel
Tel: 972-2-6757512; Fax: 972-2-6758144

The role of mast cells and their interaction with eosinophils (the allergic effector unit), in allergic diseasesasthma, atopic dermatitis, allergic rhinitis etc; Novel inhibitory and activating receptors on mast cells. Characterization and their use as a target for anti allergic therapy; mastocytosis

MADJÈNE, Lydia Celia

celia.madjene(at)inserm.fr

Inserm U 699
Immunopathologie rénale, récepteurs et inflammation
Université Paris 7, Faculté de Médecine Site Bichat
16, rue Henri Huchard
F-75870 Paris Cedex 18, FRANCE
Tel: 33 (0)1 57 27 73 45; Fax: 33 (0)1 57 27 76 61

MAURER, Marcus
MC Member

marcus.maurer(at)charite.de

Dept. of Dermatology and Allergy
Charité – Universitätsmedizin Berlin
Charitéplatz 1, D-10117 Berlin, Germany
Tel: +49 (0)30-450 518 043; Fax: +49 (0)30-450 518 919

Characterization of physiological and pathological functions of mast cells, mast cell progenitors and mast cell mediators in health and disease, investigation of the role of mast cells in innate and adaptive immunity, in host defence responses against bacteria, parasites, and viral infections, as key effector cells in allergic and other inflammatory reactions, as modulators in cancer development as well as their interaction with sensory nerves and neuropeptides.

MECHERI, Salah
MC Member

salah.mecheri(at)pasteur.fr
smecheri(at)pasteur.fr

Institut Pasteur 28 rue Dr Roux 75015 Paris France
Tel. 331 45 68 82 45
Fax 331 44 38 95 21

Title: Cellular and molecular mechanisms associated with the allergic inflammation and demonstration of their contribution to malaria pathogenesis
Our studies aim at understanding the molecular and cellular basis of the pathogenesis of murine cerebral malaria with a particular emphasis on the contribution of the host allergic inflammatory response elicited by both anopheles mosquito saliva and the Plasmodium parasite.

METZ, Martin

Martin.Metz(at)charite.de

Dept of Dermatology and Allergy,  Allergie Centrum Charité/ECARF, Charité - Universitätsmedizin Berlin,
Charitéplatz 1 - 10117 Berlin, Germany

See Frank Siebenhaar for Research Interests.

MIGALOVICH-SHEIKHET, Helena

helena.shmi(at)gmail.com

Dept. of  Pharmacology, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, The Hebrew Univ of Jerusalem, POB 12065, Jerusalem 91120, Israel
Tel: 972-2-6758746; Fax: 972-2-6758144

Allergic Effector Unit -  mast cells and eosinophils in allergic inflammation.
See also F levi-Schaffer

MINAI-FLEMINGER, Yael

yael.minai(at)mail.huji.ac.il

Dept. of  Pharmacology, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel
Tel: 972-2-6758746
Fax: 972-2-6758144

CD48 and other activating receptors on mast cells.
See also F Levi-Schaffer

MIZRAHI, Saar

saarm3(at)gmail.com

Dept. of  Pharmacology, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, POB 12065, Jerusalem 91120, Israel
Tel: 972-2-6758746
Fax: 972-2-6758144

1) Mast cell (MC) regulation by inhibitory receptors, 2) cooperation between inhibitory receptors in regulation of MC and 3) the use of inhibitory receptors for therapy of mastocytosis
See also F Levi-Schaffer

MORGADO, Jose M.

jmtmorgado(at)gmail.com

Hospital Virgen del Valle, Instituto de Mastocitosis de Castilla La Mancha, Carretera de Cobisa s/n 45071 Toledo Spain
Tel: 34-925269335

NAWIJN, Martijn
MC Substitute Member

m.c.nawijn(at)med.umcg.nl

Laboratory of Allergology and Pulmonary Diseases, Dept of Pathology and Medical Biology, UMCG Hanzeplein 1, IPC EA11 NL-9700-RB Groningen, Netherlands
Tel. (+31)503610998

Functional genomics of asthma and allergic disorders, studying susceptibility gene function through a combination of in vitro and in vivo approaches in experimental models of the human disease.

NIKOLIC, Miloš

milos.nikolic(at)ibiss.bg.ac.rs

Institute for Biological Research
"Siniša Stanković" (Laboratory of Mycology), Department of Plant Physiology, University of Belgrade; Bulevar despota Stefana 142, 11000
Belgrade, Serbia

NILSSON, Gunnar Nilsson
MC Member

Gunnar.P.Nilsson(at)ki.se

Clinical Immunology and Allergy Unit
Department of Medicine Solna
Karolinska Institutet
KS L2:04
17176 Stockholm, Sweden
tel +46 8 517 70205; cellular + 46 (0) 70 6402093

Our laboratory investigates the function of mast cells and their mediators in health and diseases; especially respiratory inflammatory disorders and mast cell activation diseases including mastocytosis

ORINSKAS, Zane

Dept. of Immunology and Cell Biology, Research Center Borstel,  Parkallee 2, D-23845 Borstel, Germany

O'SULLIVAN, Maria
MC Member

maria.osullivan(at)tcd.ie

Trinity College Dublin Trinity Centre for Health Scinece, AMNCH, Tallaght D24 Dublin Ireland
Tel. 353 1 8963843

OUDE ELBERINK, Hanneke
MC Member

j.n.g.oude.elberink(at)int.umcg.nl

University Medical Center Groningen
Hanzeplein 1
9700 RB Groningen
Netherlands
Tel. +31 50 3612945
Fax +31 50 3619308

PEJIN, Boris
Pending MC Member

brspjn(at)gmail.com

Department of Life Sciences
Institute for Multidisciplinary Research
University of Belgrade
Kneza Viseslava 1, 11030 Belgrade
Serbia

PEJLER, Gunnar

Gunnar.Pejler(at)afb.slu.se

Swedish Univ of Agricultural Sciences, Dept of Anatomy, Physiology and Biochemistry, BMC, Box 575, 751 23 Uppsala, Sweden
tel: 46 (0) 184714090
fax: 46 (0) 18 550762

PUCILLO, Carlo

carlo.pucillo(at)uniud.it

Lab. of Immunology, Dept of Medical and Biological Science, University of Udine, P.le M. Kolbe, 4, 33100 Udine, ITALY
Tel. +39 0432 494340
Fax +39 0432 494301

The laboratory is using an interdisciplinary approach that includes cellular and molecular biology, mouse genetics and immunological and biochemical methods to study the non canonical function of Mast cell beside their role in effector cell in allergic diseases. We have begun to integrate our basic research with an understanding of regulation of immune system and its failure in control of development of autoimmune disease or tumor recognition. We focus our attention on the interplay between MC and different immune and non immune cells in normal tissue as well in the contest of cancer development.

REDEGELD, Frank

f.a.m.redegeld(at)uu.nl

Division of Pharmacology,
Dept of Pharmaceutical Sciences, Faculty of Science, Utrecht University, PO BOX 80082, 3508 TB, 3584 CG Utrecht, The Netherlands
Tel: +-31-6-20252139

In my research group, we are interested in the role of non-IgE mediated mast cell activation in chronic inflammatory diseases. In particular, we study the mechanism of activation of mast cells through immunoglobulin free light chains and its pathophysiological role in autoimmune diseases, cancer, upper and lower airway diseases and food allergy. We employ in vitro techniques (e.g. primary mast cell cultures) and in vivo models (mouse models) in our research and collaborate with clinicians to translate our findings to human disease.

SAGI-EISENBERG, Ronit
MC Member

histol3(at)post.tau.ac.il

Dept. of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Tel. 972 3 6409500

1. Systematic classification of physiological and pathophysiological relevance of mediators, growth factors, specific chemokines, receptors, activators, inhibitors, ion channels.
2. Description of the function of signal transduction pathways initiated by known or newly defined activators/receptors.
We study the role of mast cells in allergic and inflammatory reactions. In particular we focus on the development of quantitative methods that would allow functional genomics analyses of mast cells and systems analyses of mast cell cross-talks with cancer cells. Employing such methods, we have recently performed a functional and phenotypic screen of Rab GTPases and identified a network of 28 Rabs, 24 of which were hitherto unappreciated.

SALUJA, Rohit
(Post Doctoral Fellow)

rohit.saluja(at)charite.de

Charité– Universitätsmedizin Berlin
Charitéplatz 1
D-10117 Berlin, Germany

SANCHEZ-MUÑOZ, Laura

lsmunoz(at)sescam.jccm.es

Médico Especialista en Inmunología, Instituto de Estudios de Mastocitosis (CLMast), Hospital Virgen del Valle Carretera Cobisa, s/n., Toledo 45071,
Spain
Tel: +34-925269350

SCHUERWEGH, Annemie

a.j.m.schuerwegh(at)lumc.nl

Leiden University Medical Center (LUMC), Dept of Rheumatology C1-R, PO BOX 9600, Albinusdreef 2, 2300 RC Leiden, The Netherlands
tel ++31 (0)71 526 3598
fax ++ 31 (0)71 526 6752
www.lumc.nl/reumatologie

Characterization of phenoytype and functional rol of mast cells as key effector cells in autoimmunity, e.g. rheumatoid arthrritis.  With focus on Toll like receptor triggering and FcReceptor  signalling in Autoimmunity

SEAF, Mansour

mansourse11(at)gmail.com

Dept. of  Pharmacology, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, The Hebrew Univ of Jerusalem, POB 12065, Jerusalem 91120, Israel
Tel: 972-2-6758746; Fax: 972-2-6758144

SFACTERIA, Alessandra

asfacteria(at)unime.it

Unit of Pathology, Department of Veterinary Public Health, Faculty of Veterinary Medicine, University of Messina, Messina 98168, Italy

Experimental and spontaneous models of disease; the stromal influence in tumor initiation and progression and the role of MCs in this setting (Veterinary pathology); kidney regeneration using fish as experimental model; investigating in cats and dogs the high occurrence of tumors of mast cells; expression of molecular markers of disease and tissue protection.  

SIEBENHAAR, Frank
MC Member

Frank.Siebenhaar(at)charite.de

Dept of Dermatology and Allergy,  Allergie Centrum Charité/ECARF, Charité - Universitätsmedizin Berlin,
Charitéplatz 1 - 10117 Berlin, Germany
Tel. +49 30 450 618 295

Characterization of physiological and pathological functions of mast cells, mast cell progenitors and mast cell mediators in health and disease, investigation of the role of mast cells in innate and adaptive immunity, in host defence responses against bacteria, parasites, and viral infections, as key effector cells in allergic and other inflammatory reactions, as modulators in cancer development as well as their interaction with sensory nerves and neuropeptides.

SINGH GANGWAR, Roopesh

roopeshg(at)ekmd.huji.ac.il

Dept. of  Pharmacology, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, The Hebrew Univ of Jerusalem, POB 12065, Jerusalem 91120, Israel
Tel: 972-2-6758746; Fax: 972-2-6758144

Role of CD48 and 2B4 as expressed by mast cells in atopic dermatitis.
See also F Levi-Schaffer

SPYRIDON, Chalkiadakis

hellas15(at)otenet.gr

Dept of Pharmacology, Medical School, University of  Athens, Greece

H3R/H4R in ocular allergic & inflammatory diseases

TILIGADA, Ekaterini

aityliga(at)med.uoa.gr

Dept of Pharmacology, Medical School, University of Athens, M. Asias 75, GR-11527 Athens,  Greece
Tel - Fax: +30 2107462575 - +30 2107462554

The role of histamine in immunopharmacology and inflammation.
The functional role of the histamine H4 receptor (H4R) in mast cell-mediated inflammation in in vivo models of experimental conjunctivitis and arthritis. We focus on the investigation of the possible peripheral autoregulatory role of H4R (in mast-cell function) in boold vessels and ocular tissues using novel H4R agonists/antagonists. The main analytical techniques are ex vivo histamine fluorophotometric quantification, cytokine determination by ELISA and cytological evaluation of MC degranulation in the tissues.

TROSIEN, Julia

julia-ariane.trosien(at)charite.de

Dept. of Dermatology and Allergy
Allergie-Centrum-Charité/ECARF
Charité - Universitätsmedizin Berlin
Charitéplatz 1, 10117
Berlin, Germany
Phone: +49 30 450 518 337
Fax: +49 30 450 518 972

VAJDA, Vladimir

vladimir.vajda(at)gmail.com

Dept. of  Pharmacology, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, The Hebrew Univ of Jerusalem, POB 12065, Jerusalem 91120, Israel
Tel: 972-2-6758746; Fax: 972-2-6758144

Endocannabinoids and mast cells and allergy.
See also F. Levi-Schaffer

VODENICHAROV, Angel
MC Member

angvod(at)uni-sz.bg

Trakia University Stara Zagora, 6000 Stara Zagora, Bulgaria
Tel. +359 42 699 645
Fax + 359 42 699 646

histo- and immunohistochemistry characteristics of mast cells cells, localized mostly in blood vessels, autonomic ganglia and autonomic nerves, and in smooth muscle layers of some internal organs, mainly in domestic pig. We have evidenced several mediators in porcine mast cells, such as histamine, dopamine (via tyrosine-hydroxylase), heparin (via berberin sulphate), endothelin, vasoactive intestinal polypeptide, nitric oxide (via NADPH-diaphorase and NOS), etc.

WAN, Daniel

paxdw(at)nottingham.ac.uk

The School of Pharmacy,  Division of Molecular and Cellular Science, Boots Science Building, Science Road, Nottingham NG7 2RD, UK
Tel: 44 (0)115 8466073; Fax: 44(0)115 9515102

YILMAZ,  M. Sertac

yilmaz(at)gmail.com

Department of Medical Pharmacology
Uludag University Medical School
16059, Bursa, Turkey
+90 224 295 3566 (work)
+90 532 265 7727 (mobile)

Shock, particularly septic shock, and the role of mast cells in septic shock conditions

XIANG, Zou

zou.xiang(at)gu.se

Department of Microbiology and Immunology, Sahlgrenska Academy, University of Gothenburg, Box 435, 40530 Gothenburg, Sweden
Tel: +46-31-7866322
Fax: +46-31-7866330

Research focuses on two main topics 1) The effects of the inhibitory IgG receptor FcgammaRIIb on mast cell apoptosis. 2) Optimizing the adjuvant effects in boosting mucosal vaccination by activating mast cells

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